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Sequel to the 1996 spin-off of the popular 1960s espionage series. Impossible Missions Force's Ethan Hunt (Tom Cruise) is charged with tracking down renegade fellow agent Sean Ambrose (Dougray Scott), who has stolen the only known supply of Bellophron - the antidote to the man-made virus Chimera. Ethan enlists the help of Ambrose's ex-girlfriend, Nyah Nordoff-Hall (Thandiwe Newton), and although the pair have fallen in love, Nyah agrees to return to Ambrose in order to gain information. However, Ambrose now intends to trigger an epidemic of Chimera in order to sell Bellophron to the highest bidder and, when he becomes suspicious of Nyah, decides to use her as a guinea pig.