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Kate Beckinsale, Jim Sturgess and Ben Kingsley star in this thriller based on Edgar Allan Poe's short story 'The System of Doctor Tarr and Professor Fether'. Set in 1899, the film follows medical school graduate Dr. Edward Newgate (Sturgess) as he arrives at Stonehearst Asylum, an institute for the mentally insane. There he meets the leader of the organisation, Dr. Silas Lamb (Kingsley), and one of his patients, Eliza Graves (Beckinsale), who Newgate becomes enamoured with. Shocked by the unconventional methods Lamb uses to treat his patients, Newgate decides to leave the asylum, determined to take Eliza with him. However, he discovers that everything is not as it seems and escaping turns out to be more difficult than he imagined... The film also stars Michael Caine, David Thewlis and Brendan Gleeson.