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Ciro Guerra directs this action adventure based on the diary by Theodor Koch-Grunberg and Richard Evan Schultes. Set in the Colombian Amazon, the story follows shaman Karamakate (Nilbio Torres/Antonio Bolivar) who helps German scientist Theo (Jan Bijvoet) in 1909 and, 30 years later, American scientist Evan (Brionne Davis), in their search for the yakruna, a rare and sacred healing plant. Their journeys take them through the mysterious and wild rainforest, where they encounter the destruction of indigenous culture by settlers and industrialists. The film was nominated for the Academy Award for Best Foreign Language Film.